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Enzyme Inhibition: Competitive and Uncompetitive
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Note: this explanation is best understood if you have a Lineweaver-Burke plot and a velocity vs. concentration graph available while reading it.
When you look at an enzyme reaction, you’re really looking at two reactions:
E+S ES –> E + P
So in those rxns, E is the enzyme, S is the substrate, and P is the product. You’ll notice that substrate binding is reversible, so you could say that we’re looking at three possible reactions. Call the first forward reaction R1. Call the reverse of that reaction R2. Call the release of product from the enzyme R3.
Tags: Competitive, Enzyme, Inhibition, Uncompetitive